The Anti-CD62L antibody from MyBioSource.com is a Rabbit Polyclonal antibody to A.11, CD62L, LAM1, LEU8, SELE, and SELL. This antibody recognizes Mouse, and Rat antigen. The Anti-CD62L antibody has been validated for the following applications: Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for L-selectin(SELL) detection. Tested with WB in Mouse, Rat.
Background: L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17. SELL(L-selectin)is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point